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  • Table S5 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S5. Nonsynonymous single nucleotide variants (SNVs) and insertions/deletions (indels) identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Exome Sequencing
    Neoplasms/drug therapy
    Nucleotides
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S1 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S1. Massively Parallel Sequencing (MPS) metrics and cancer sample characteristics."

    Subject
    Clinical Trial, Phase II
    Everolimus
    High-Throughput Nucleotide Sequencing
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S2 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S2. Demographic and clinical characteristics of 30 cancer patients with mTOR pathway mutations. S2.1. Master table showing a summary of demographic characteristics and clinical outcomes. S2.2. Prior systemic treatment regimens. S2.3. Objective response to everolimus according to RECIST v1.1 criteria. S2.4. Toxicity profile of patients according to CTCAE v4.0."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S3 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S3. Toxicities (any level) occurring in at least two patients, grouped by CTCAE v4.0 categories. For patients with more than one adverse event per category, only the highest-grade event was counted."

    Subject
    Clinical Trial, Phase II
    Drug-Related Side Effects and Adverse Reactions
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S6 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare: "Table S6. Copy number alterations (CNAs) in cancer genes identified by whole exome sequencing (WES) and/or initial panel sequencing. Each sheet is a different tumor sample."

    Subject
    Clinical Trial, Phase II
    DNA Copy Number Variations
    Everolimus
    High-Throughput Nucleotide Sequencing
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Access Rights
    Free to All
  • Table S4 from Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations

    Authors
    Adib, Elio
    Klonowska, Katarzyna
    Giannikou, Krinio
    Do, Khanh T.
    15 more author(s)...
    Description

    Description from Figshare; "Table S4. Inactivating mutations in TSC1/TSC2 and activating mutation in MTOR identified in 30 patients in the clinical trial - clonality and biallelic TSC1/TSC2 inactivation status."

    Subject
    Clinical Trial, Phase II
    Everolimus
    Neoplasms/drug therapy
    TOR Serine-Threonine Kinases
    Tuberous Sclerosis Complex 1 Protein
    Tuberous Sclerosis Complex 2 Protein
    Access Rights
    Free to All
  • Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial

    Authors
    Burman, Bharat
    Jain, Swati
    Fitzgerald, Conall W.R.
    Sherman, Eric J.
    22 more author(s)...
    Description

    Description from Zenodo: "This is a de-identified dataset accompanying the Nature Medicine publication titled "Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial", by Vos et al. (DOI: https://doi.org/10.1038/s41591-023-02518-x). It contains the clinical features and processed data of 64 patients with salivary gland cancer, treated with nivolumab and ipilimumab immunotherapy....

    Subject
    Clinical Trial, Phase II
    Immunotherapy
    Ipilimumab
    Nivolumab
    Salivary Gland Neoplasms
    Access Rights
    Free to All
  • Determinants of Response to Nivolumab plus Ipilimumab in a Phase II Trial of Advanced Salivary Gland Cancer Patients

    Description

    Description from BioProject: "Salivary gland cancers (SGCs) are rare, aggressive cancers that lack effective treatments in the metastatic setting. We report the clinical results and immunogenomic correlates of response from a phase II trial evaluating nivolumab (anti-PD1) and ipilimumab (anti-CTLA4) in metastatic SGC patients."

    Subject
    Clinical Trial, Phase II
    Exome Sequencing
    Ipilimumab
    Nivolumab
    RNA-Seq
    Salivary Gland Neoplasms
    Access Rights
    Free to All